ScourGuard 4KC is for vaccination of healthy, pregnant cows and heifers as an aid in preventing diarrhea in their calves caused by bovine rotavirus (serotypes G6 and G10), bovine coronavirus, enterotoxigenic strains of Escherichia coli having the K99 pili adherence factor, and Clostridium perfringens type C. ScourGuard 4KC contains a liquid preparation of inactivated bovine rotavirus serotypes G6 G10, coronavirus, a K99 E. coli bacterin, and Clostridium perfringens type C toxoid. The vaccine is adjuvanted to enhance the immune response.