A combination bacterin vaccine that aids in the control of pinkeye caused by Moraxella bovis strains expressing pili similar to those expressed by isolates referred to as strains EPP 63, FLA 64, and SAH 38, and against diseases caused by Clostridium chauvoei, C. septicum, C. novyi Type B, C. sordellii and C. perfringens Types C and D. Immunity is also provided against C. perfringens Type B.